Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.
Identifieur interne : 000A31 ( Main/Exploration ); précédent : 000A30; suivant : 000A32Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.
Auteurs : Qian Li [République populaire de Chine] ; Chengmei Liu [République populaire de Chine] ; Ti Li [République populaire de Chine] ; David Julian Mcclements [États-Unis] ; Yinxin Fu [République populaire de Chine] ; Jiyan Liu [République populaire de Chine]Source :
- Food research international (Ottawa, Ont.) [ 1873-7145 ] ; 2018.
Descripteurs français
- KwdFr :
- Anacardiaceae (), Antinéoplasiques (), Antinéoplasiques (analyse), Antinéoplasiques (pharmacologie), Apoptose (), Cellules Caco-2, Composés phytochimiques (), Composés phytochimiques (analyse), Composés phytochimiques (pharmacologie), Extraits de plantes (), Fruit (), Humains, Proanthocyanidines (), Proanthocyanidines (analyse), Proanthocyanidines (pharmacologie), Prolifération cellulaire ().
- MESH :
- analyse : Antinéoplasiques, Composés phytochimiques, Proanthocyanidines.
- pharmacologie : Antinéoplasiques, Composés phytochimiques, Proanthocyanidines.
- Anacardiaceae, Antinéoplasiques, Apoptose, Cellules Caco-2, Composés phytochimiques, Extraits de plantes, Fruit, Humains, Proanthocyanidines, Prolifération cellulaire.
English descriptors
- KwdEn :
- Anacardiaceae (chemistry), Antineoplastic Agents (analysis), Antineoplastic Agents (chemistry), Antineoplastic Agents (pharmacology), Apoptosis (drug effects), Caco-2 Cells, Cell Proliferation (drug effects), Fruit (chemistry), Humans, Phytochemicals (analysis), Phytochemicals (chemistry), Phytochemicals (pharmacology), Plant Extracts (chemistry), Proanthocyanidins (analysis), Proanthocyanidins (chemistry), Proanthocyanidins (pharmacology).
- MESH :
- chemical , analysis : Antineoplastic Agents, Phytochemicals, Proanthocyanidins.
- chemistry : Anacardiaceae, Antineoplastic Agents, Fruit, Phytochemicals, Plant Extracts, Proanthocyanidins.
- drug effects : Apoptosis, Cell Proliferation.
- chemical , pharmacology : Antineoplastic Agents, Phytochemicals, Proanthocyanidins.
- Caco-2 Cells, Humans.
Abstract
Epidemiological studies had indicated that the incidence of colorectal cancer is inversely correlated to the consumption of proanthocyanidins (PAs). In this study, five PAs fractions isolated from Choerospondias axillaris fruit peels with different mean degree of polymerization (mDP) were characterized and their antiproliferative effects on Caco-2 cells were investigated. MALDI-TOF-MS results indicated that PAs fractions were composed of procyanidins with DP up to 13-mers. All PAs fractions induced dose and time-dependent reductions of Caco-2 cell viability. The IC50 values of PAs fractions with increasing mDP were 240 ± 16.0, 143 ± 9.53, 87.0 ± 3.55, 44.3 ± 4.89, and 42.8 ± 2.20 μg/mL after 24 h incubation, respectively. The observed reduction in Caco-2 cell viability was due to apoptosis via the activation of caspase-9, caspase-3, caspase-8 and the elevation of intracellular ROS generation. Moreover, the extent of the reduction in cell viability after exposure to PAs fractions was positively correlated with their mDP and galloylation. These results indicate that Choerospondias axillaris peel is a potential source of natural chemopreventive agents for the treatment of colorectal cancer.
DOI: 10.1016/j.foodres.2018.07.006
PubMed: 30195524
Affiliations:
- République populaire de Chine, États-Unis
- Massachusetts
- Amherst (Massachusetts)
- Université du Massachusetts
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Le document en format XML
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In this study, five PAs fractions isolated from Choerospondias axillaris fruit peels with different mean degree of polymerization (mDP) were characterized and their antiproliferative effects on Caco-2 cells were investigated. MALDI-TOF-MS results indicated that PAs fractions were composed of procyanidins with DP up to 13-mers. All PAs fractions induced dose and time-dependent reductions of Caco-2 cell viability. The IC<sub>50</sub> values of PAs fractions with increasing mDP were 240 ± 16.0, 143 ± 9.53, 87.0 ± 3.55, 44.3 ± 4.89, and 42.8 ± 2.20 μg/mL after 24 h incubation, respectively. The observed reduction in Caco-2 cell viability was due to apoptosis via the activation of caspase-9, caspase-3, caspase-8 and the elevation of intracellular ROS generation. Moreover, the extent of the reduction in cell viability after exposure to PAs fractions was positively correlated with their mDP and galloylation. These results indicate that Choerospondias axillaris peel is a potential source of natural chemopreventive agents for the treatment of colorectal cancer.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Amherst (Massachusetts)</li></settlement><orgName><li>Université du Massachusetts</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name></noRegion><name sortKey="Fu, Yinxin" sort="Fu, Yinxin" uniqKey="Fu Y" first="Yinxin" last="Fu">Yinxin Fu</name><name sortKey="Li, Ti" sort="Li, Ti" uniqKey="Li T" first="Ti" last="Li">Ti Li</name><name sortKey="Liu, Chengmei" sort="Liu, Chengmei" uniqKey="Liu C" first="Chengmei" last="Liu">Chengmei Liu</name><name sortKey="Liu, Jiyan" sort="Liu, Jiyan" uniqKey="Liu J" first="Jiyan" last="Liu">Jiyan Liu</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mcclements, David Julian" sort="Mcclements, David Julian" uniqKey="Mcclements D" first="David Julian" last="Mcclements">David Julian Mcclements</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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